Fundamentals of Molecular Virology (2nd Ed)
English | eBook | Size: 85.51 MB
This new, fully revised second edition of Fundamentals of Molecular Virology is designed for university students learning about virology at the undergraduate or graduate level. Chapters cover most of the major virus families, emphasizing the unique features of each virus family. These chapters are designed to tell stories about the viruses covered, and include information on discovery, diseases and pathogenesis, virus structure, steps in viral replication, and interaction with cellular signaling pathways. This approach portrays the “personality” of each virus, helping students to learn the material and to build up their knowledge of virology, starting with smaller and simpler viruses and proceeding to more complex viruses.
FEATURES OF FUNDAMENTALS OF MOLECULAR VIROLOGY:
– Clear style. Written in a simple and clear style for students with a background in cell and molecular biology.
– Full-color figures. Numerous full-color figures complement the text and illustrate virus structure, genome organization, and individual steps in virus replication.
– Extended coverage. This second edition has five new chapters: Cucumber Mosaic Virus; Viruses of Archaea; Viruses of Algae and the giant Mimivirus; Intrinsic Cellular Responses Against Virus Infection; and Innate and Adaptive Immune Responses to Virus Infection. All other chapters have been revised and updated.
– Study aids include thumbnail sketches of each virus group, informative chapter subheadings, and a comprehensive glossary with definitions of numerous terms.
– Chapter introductions give historical background and information about viral diseases.
– Text boxes throughout the book feature exciting and current developments in molecular virology or practical applications of viruses in science and medicine.
– Key Terms, Fundamental Concepts, and Review Questions at the end of each chapter help students review and organize information they have learned.
– Information on human pathogens. Includes chapters on important human pathogens including herpes viruses, hepatitis B and C viruses, human immunodeficiency virus, influenza viruses, measles virus, poliovirus, smallpox virus, West Nile virus, and others.
BRIEF CONTENTS
SECTION I: INTRODUCTION TO VIROLOGY
1. Introduction to Virology 2
2. Virus Structure and Assembly 18
3. Virus Classification: The World of Viruses 31
4. Virus Entry 45
SECTION II: VIRUSES OF BACTERIA AND ARCHAEA
5. Single-Stranded RNA Bacteriophages 59
6. Microviruses 69
7. Bacteriophage T7 77
8. Bacteriophage Lambda 85
9. Viruses of Archaea 97
SECTION III: POSITIVE-STRAND RNA VIRUSES OF EUKARYOTES
10. Cucumber Mosaic Virus 112
11. Picornaviruses 125
12. Flaviviruses 137
13. Togaviruses 148
14. Coronaviruses 159
SECTION IV: NEGATIVE-STRAND AND DOUBLE-STRANDED RNA VIRUSES OF EUKARYOTES
15. Paramyxoviruses and Rhabdoviruses 175
16. Filoviruses 188
17. Bunyaviruses 200
18. Influenza Viruses 210
19. Reoviruses 225
SECTION V: SMALL DNA VIRUSES OF EUKARYOTES
20. Parvoviruses 238
21. Polyomaviruses 247
22. Papillomaviruses 263
SECTION VI: LARGER DNA VIRUSES OF EUKARYOTES
23. Adenoviruses 274
24. Herpesviruses 285
25. Baculoviruses 302
26. Poxviruses 312
27. Viruses of Algae and Mimivirus 325
SECTION VII: VIRUSES THAT USE A REVERSE TRANSCRIPTASE
28. Retroviruses 342
29. Human Immunodeficiency Virus 354
30. Hepadnaviruses 365
SECTION VIII: VIROIDS AND PRIONS
31. Viroids and Hepatitis Delta Virus 378
32. Prions 387
SECTION IX: HOST DEFENSES AGAINST VIRUS INFECTION
33. Intrinsic Cellular Defenses Against Virus Infection 398
34. Innate and Adaptive Immune Responses to Virus Infection 415
SECTION X: ANTIVIRAL AGENTS AND VIRUS VECTORS
35. Antiviral Vaccines 428
36. Antiviral Chemotherapy 444
37. Eukaryotic Virus Vectors 456
GLOSSARY 471
CREDITS 484
NAME INDEX 489
SUBJECT INDEX 491
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